2 edition of Development of chemotherapeutic agents for parasitic diseases found in the catalog.
Development of chemotherapeutic agents for parasitic diseases
by American Elsevier Pub. Co
Written in English
|The Physical Object|
|Number of Pages||264|
Currently, the chemotherapy remains essential component of both clinical management and disease control programmer in endemic areas. The drugs in use as anti-protozoan agents were discovered over 50 years and a number of factors limit their utility such as: high cost, poor compliance, drug resistance, low efficacy and poor safety. Many parasitic protozoans and helminths synthesize unusual glycan structures and glycan-binding proteins (GBPs) that are often antigenic and involved in host invasion and parasitism. This chapter discusses these parasites and the roles of glycoconjugates in the disease process. Protozoan parasites have evolved unique lifestyles: They shuttle between insect vectors and vertebrate hosts.
chemotherapy agents commonly used to treat parasitic diseases are “ dated ” and have limited ef ﬁ cacy (T able 1). During the past decades, the development of novel chemother apy agents to. The specific chemotherapy currently employed for the treatment of these diseases has serious limitations due to lack of efficacy, toxic side effects, growth of drug-resistance and high costs. Thus, it is urgent to develop new chemotherapeutic agents that are more effective, safe and accessible.
An historical account is given of the development of chemotherapy from the days of Hippocrates to the present time. The contents of the early chapters discuss the use, as chemotherapeutic agents, of dyes derived from coal tar, then the application of aniline dyes for the staining of tissues and bacteria. Chapter IV deals with the' endeavour to find suitable chemical reagents to destroy. Recent progress in vaccine development for human parasitic infections holds promise for the control of several diseases. While the goal of chemotherapy is to temporarily cure or reduce infection intensities, morbidity, and transmission, vaccines would also reduce worm burdens and, ideally, induce long‐lasting protective host immune responses.
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Get this from a library. Development of chemotherapeutic agents for parasitic diseases: proceedings of the international conference, Versailles, 11.
This new environment made the symposium on "Drugs against Parasitic Diseases" that was held in Montpellier from May particularly timely. The goal of the meeting was the development of a framework for research into antiparasitic drugs into the 21 st century.
Parasitic diseases are. Genre/Form: Electronic books: Additional Physical Format: Print version: Chemotherapy of parasitic diseases. New York: Plenum Press, © (DLC) Parasitic infections are the most prevalent of human diseases.
Parasites’ effective evasion of their hosts’ immune defenses and their complex physiology and life cycles make them especially resistant to attack by chemotherapeutic agents. Researchers continue to face the challenge of designing drugs to successfully counteract them.
Parasitic infections are the most prevalent of human diseases, and researchers continue to face the challenge of designing drugs to successfully counteract them. Chemotherapeutic Targets in Parasites analyzes the critical metabolic reactions and structural features essential for parasite survival, and advocates the latest molecular strategies.
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Being the cause for significant amount of morbidities and mortalities, parasitic diseases remain the major challenge for the healthcare community due to the limitations associated with the current chemotherapeutics.
Drug discovery/invention can be achieved by collaborative efforts of biotechnologists and pharmacists for identifying potential candidates and successfully turn them into medicine.
Craig M. Wilson, in Principles and Practice of Pediatric Infectious Diseases (Fourth Edition), Nitazoxanide. Nitazoxanide is an antiparasitic agent with specific indications for treatment of cryptosporidiosis and giardiasis in children.
16 Nitazoxanide is a nitrothiazolyl-salicylamide derivative, whose activity appears to be at the level of electron transfer of anaerobic metabolism. INTRODUCTION.
Vaccine development against eukaryotic parasites has stalled or has progressed slowly. As a consequence, the development of novel chemotherapies against these parasites remains a priority ().Drug resistance is also a major looming threat for both malaria and African trypanosomiasis; resistance in parasites and their vectors threatens to reverse the gains associated with decades.
Most people associate the term chemotherapy with treatments for cancer. However, chemotherapy is actually a broader term that refers to any use of chemicals or drugs to treat disease. Chemotherapy may involve drugs that target cancerous cells or tissues, or it may involve antimicrobial drugs that target infectious microorganisms.
Antimicrobial. -developed the concept of chemotherapy as a way of treating microbial diseases-predicted the development of chemotherapeutic agents that would kill pathogens without harming the host.
-a chemotherapeutic agent used to treat microbial infection;should not cause excessive harm to normal microbiota -used to treat parasitic protozoan.
The neglected tropical diseases (NTDs) consist of a group of parasitic and bacterial infections that affect >20% of the world's current population. Up to 90% of those affected live in remote, rural areas or in urban slums in Africa, Asia, and Latin America, areas that are characterized by a vicious circle of sustained poverty and endemic.
The aim of chemotherapy as defined by the author is the sterilization of the infected body by means of substances of defined chemical constitution in contrast to that effected by chemically undefined serum antibodies. In the first part of the work the development of chemotherapy is traced from the point of view of relationships between chemical constitution and therapeutic action; the important.
ADVERTISEMENTS: In this article we will discuss about: 1. Introduction to Chemotherapeutic Agents 2. Definition of Chemotherapeutic Agents 3. Short History 4. Groups. Introduction to Chemotherapeutic Agents: For centuries, physicians believed that heroic measures were necessary to save patients from the ravages of infectious diseases.
They prescribed frightening courses of purges. Get this from a library. Chemotherapeutic targets in parasites: contemporary strategies. [Tag E Mansour; Joan MacKinnon Mansour] -- Chemotherapeutic Targets in Parasites analyzes the critical metabolic reactions and structural features essential for parasite survival, and advocates the latest molecular strategies with which to.
By Georges Simenon - chemotherapeutic targets in parasites contemporary strategies this book analyses the critical metabolic reactions and structural features essential for parasite survival and advocates the latest molecular and biochemical strategies with which to identify effective antiparasitic.
Entamoeba histolytica. histolytica is the causative agent of amoebiasis, a contagious disease of the human gastrointestinal tract (Tengku and Norhayati, ; Watanabe et al., ).It is an organism implicated in both diarrheal disease and invasive disease such as liver abscesses.
Metronidazole (14) is the first line medication used against the infection but long-term uses produce several. Parasitic diseases continue to be the major public health problems in tropical developing countries. These are responsible for a high degree of morbidity, mortality and socio-economic under-development in these regions.
According to WHO estimates the annual death toll due to parasitic diseases is nearly million throughout the world [1,2]. The author, who is with Janssen Pharmaceutica Research Laboratories, Belgium, reviews the present situation with particular reference to drugs for malaria, trypanosome and leishmanial infections, schistosome infections, and tapeworm and nematode infections.
There are 99 references. He considers that " although several good antiparasitic agents are available, new drugs are needed for the.
Chemotherapy of Parasitic Diseases - Ebook written by W.C. Campbell, R.S. Rew. Read this book using Google Play Books app on your PC, android, iOS devices. Download for offline reading, highlight, bookmark or take notes while you read Chemotherapy of Parasitic Diseases. This book analyses the critical metabolic reactions and structural features essential for parasite survival and advocates the latest molecular and biochemical strategies with which to identify effective antiparasitic agents.
It contains 8 chapters. An introduction to the early development of parasite chemotherapy is followed by an overview of biophysical techniques and genomic and proteomic. As shown in Tablethe GBD from tropical parasitic diseases is total, these infections account for approximately 74 million DALYs annually, with malaria being the largest contributor, followed by leishmaniasis, schistosomiasis, and trypanosomiasis, in that order.
Efforts to create vaccines against these parasitic diseases have not been expressly successful in overcoming.The use of chemotherapy to treat cancer began at the start of the 20th century with attempts to narrow the universe of chemicals that might affect the disease by developing methods to screen chemicals using transplantable tumors in rodents.
It was, however, four World War II–related programs, and the effects of drugs that evolved from them, that provided the impetus to establish in the.